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174 Subtypes • 140 Genes
Currently Indexed
Updated: August 17, 2026
Where to start?
Start here if:
- New diagnosis
- First exposure
- Family member with CMT
- “I don’t know what this even is”
- Just looking for basic info about CMT
Start here if:
- You have a subtype, want the specifics
- You need subtype-specific symptoms
- Your diagnosis is weird
- You want to dig deeper
- You want details, not bloat
Start here if:
- You’re a researcher/scientist and need details about CMT genes
- You have a CMT gene and need to know its function
- You have a gene, but don’t know if it’s implicated in CMT
- You like browsing gene tables
Start here if:
- You know the gene, but want the how
- You want to know what the variant does
- You want the why, not just the label
- You’re comparing subtypes
Start here if:
- Genetics came up
- Testing was mentioned
- You’re not sure why testing matters
- You want the bigger picture
- You need info to bring to your doctor
Common CMT Confusions
- I was told I have PMP22. What is this?
- So, CMT2A1, CMT2A2, CMT2A2A = CMT2A?
- Is HNPP really a CMT subtype?
- What is CMT1F/2E?
- Can CMT affect breathing?
- Is CMT really muscular dystrophy?
This Month’s Featured CMT Subtype
Featured Subtype
What Is CMT1B?
CMT1B is a type of CMT caused by mutations in the MPZ gene. This gene provides instructions for making myelin protein zero, a crucial structural protein essential for the formation of normal peripheral nerve myelin. Mutations in the MPZ gene disrupt the formation and stability of myelin, leading to slowed nerve signal transmission.
The Dorsal Root
Long-form discussions for the questions search can’t answer yet.
When you need:
- Context, not keywords
- Deeper dives without the bloat
A Name That Does Too Much Work
AwarenessJean-Martin Charcot's name appears throughout medicine, but nowhere does it create more confusion than in the foot. Learn why the CMT foot and Charcot neuroarthropathy, also known as Charcot foot, share a name yet differ in how they develop, appear, and are managed.
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Error 404: Gene Not Found
AwarenessCMT genetic testing often fails to identify the cause of the disease, even when comprehensive panels are used. Here, we discuss why this happens, what genetic tests can and cannot do, and why a negative result still matters.
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Does CMT Skip a Generation? Can It?
AwarenessThe idea that CMT skips a generation is a misconception rooted in complex inheritance patterns. This article explains how dominant, recessive, X-Linked, and de novo mutations interact, and why CMT doesn't skip a generation.
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Where’d It Come From? Where’s It Going?
AwarenessCMT is often described as a single disease, but genetically it is anything but. From autosomal and X-Linked inheritance to de novo and mitochondrial mutations, this piece explains how CMT begins, how it’s passed on, and why family history doesn’t always tell the full story.
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