CMT Genetics

Just genetics. Noise-free.

What’s in a name?

  • The classifications defined
  • From historic to current
  • Roussy-Lévy
  • HNPP
  • Dejerine-Sottas

CMT. Curated.

  • CMT genes and subtypes
  • Easy to use
  • Subtype-specific symptoms
  • Core genetic data
  • Reference publications

The how, not the what

  • Mechanisms by gene
  • What the variant does
  • Loss vs gain of function
  • Why subtypes differ
  • Curated from publications

The info that matters

  • Types of tests
  • When to test
  • Genetic test limitations
  • Who to see
  • Commonly ordered tests

Explore More

The Dorsal Root

More From The Dorsal Root
Jean-Martin Charcot lecturing at the Salpêtrière while comparing anatomical illustrations of a cavovarus Charcot-Marie-Tooth (CMT) foot and a Charcot neuroarthropathy foot, highlighting two different conditions that share the Charcot name.

A Name That Does Too Much Work

Jean-Martin Charcot's name appears throughout medicine, but nowhere does it create more confusion than in the foot. Learn why the CMT foot and Charcot neuroarthropathy, also known as Charcot foot, share a name yet differ in how they develop, appear, and are managed.

Close-up of a doctor’s hand holding a prescription pad while a patient’s wrist is wrapped with metal chains.

When Medicine Lost Its Compass

Evidence failed not because it was wrong, but because it was weaponized. I lived the downstream effects of that failure for more than a decade. This is what happens when medicine forgets that data always ends in a human being.

Illustrated graphic showing large ‘404’ numerals with people interacting with data screens and servers, alongside text reading ‘CMT Genetic Testing Error 404: Gene Not Found’ and ‘Examining Why Less Than Half of All Who Have Charcot-Marie-Tooth Disease Are Not Able to Obtain Genetic Confirmation of Their Disease.

Error 404: Gene Not Found

CMT genetic testing often fails to identify the cause of the disease, even when comprehensive panels are used. Here, we discuss why this happens, what genetic tests can and cannot do, and why a negative result still matters.