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De Novo - Charcot-Marie-Tooth Disease | Experts in CMT

De Novo

A genetic alteration that is present for the first time in one family member as a result of a variant (mutation) in a germ cell (egg or sperm) of one of the parents, or a variant that arises in the fertilized egg itself during early embryogenesis. Also called: de novo variant, new mutation, or new variant.

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