Homozygous (hoh-moh-ZY-gus), as related to genetics, refers to having inherited the same versions (alleles) of a genomic marker from each biological parent. Thus, an individual who is homozygous for a genomic marker has two identical versions of that marker. By contrast, an individual who is heterozygous has two different versions. In CMT, a recessive subtype is homozygous, meaning two copies of the mutated gene, one from each parent, are needed to cause the disease.
A Name That Does Too Much Work
Jean-Martin Charcot's name appears throughout medicine, but nowhere does it create more confusion than in the foot. Learn why the CMT foot and Charcot neuroarthropathy, also known as Charcot foot, share a name yet differ in how they develop, appear, and are managed.
