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Homozygous - Charcot-Marie-Tooth Disease | Experts in CMT

Homozygous

A Matching Pair

Homozygous (hoh-moh-ZY-gus), as related to genetics, refers to having inherited the same versions (alleles) of a genomic marker from each biological parent. Thus, an individual who is homozygous for a genomic marker has two identical versions of that marker. By contrast, an individual who is heterozygous has two different versions. In CMT, a recessive subtype is homozygous, meaning two copies of the mutated gene, one from each parent, are needed to cause the disease.

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