VUS

Variant of Unknown Significance

The acronym for Variant of unknown or uncertain significance. A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and VUS.

Source

← Previous Term

Return to The Glossary

Next Term →

The Dorsal Root

A Name That Does Too Much Work

Jean-Martin Charcot's name appears throughout medicine, but nowhere does it create more confusion than in the foot. Learn why the CMT foot and Charcot neuroarthropathy, also known as Charcot foot, share a name yet differ in how they develop, appear, and are managed.

Close-up of a doctor’s hand holding a prescription pad while a patient’s wrist is wrapped with metal chains.

When Medicine Lost Its Compass

Evidence failed not because it was wrong, but because it was weaponized. I lived the downstream effects of that failure for more than a decade. This is what happens when medicine forgets that data always ends in a human being.

Illustrated graphic showing large ‘404’ numerals with people interacting with data screens and servers, alongside text reading ‘CMT Genetic Testing Error 404: Gene Not Found’ and ‘Examining Why Less Than Half of All Who Have Charcot-Marie-Tooth Disease Are Not Able to Obtain Genetic Confirmation of Their Disease.

Error 404: Gene Not Found

CMT genetic testing often fails to identify the cause of the disease, even when comprehensive panels are used. Here, we discuss why this happens, what genetic tests can and cannot do, and why a negative result still matters.

Experts in CMT

Detroit, Michigan, USA

All information published on this website is provided for informational and reference purposes only and should not be construed as medical advice or as a medical diagnosis. This website is not intended to replace or to substitute the opinion and advice of your physician. Always consult with your physician.

Do Not Sell My Data

You have the right to request that your personal data not be sold. To make this request, complete this form.

Name

Request Received

Your request has been received. Your personal data will not be sold or transferred to a third party.

Do Not Sell My Data

Can CMT Affect Breathing?

The CMT Subtype Browser

The CMT Gene Browser

The CMT Variant Mechanisms Browser