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Penetrance - Charcot-Marie-Tooth Disease | Experts in CMT

Penetrance

Does It Show?

Penetrance (PEN-uh-trunss) is the proportion of people carrying a particular gene variant who actually show the associated trait or disease. When everyone with the variant shows the trait, penetrance is complete; when only some do, it is called reduced or incomplete penetrance. Reduced penetrance is thought to result from a mix of genetic, environmental, and lifestyle factors, and it helps explain why a dominant CMT variant can affect family members to very different degrees.

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