A variant is any change in the DNA sequence of a gene compared with the usual reference sequence. Variants can be harmful, harmless, or beneficial, and they may be inherited or arise anew. In CMT genetic testing, the change identified in a gene is referred to as a variant, and it is then classified by its likely effect, such as pathogenic or a VUS. Variant is the modern term for what was long called a mutation.
When Medicine Lost Its Compass
Evidence failed not because it was wrong, but because it was weaponized. I lived the downstream effects of that failure for more than a decade. This is what happens when medicine forgets that data always ends in a human being.
