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X-Linked - Charcot-Marie-Tooth Disease | Experts in CMT

X-Linked

On the X

X-linked refers to genes located on the X chromosome, and to the traits or diseases caused by those genes. Because males have a single X chromosome and females have two, X-linked diseases often affect males more consistently, while a female’s second X can offset the effect. In CMT, the X-linked forms follow this pattern and include X-linked dominant and X-linked recessive inheritance.

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Jean-Martin Charcot lecturing at the Salpêtrière while comparing anatomical illustrations of a cavovarus Charcot-Marie-Tooth (CMT) foot and a Charcot neuroarthropathy foot, highlighting two different conditions that share the Charcot name.


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Illustrated graphic showing large ‘404’ numerals with people interacting with data screens and servers, alongside text reading ‘CMT Genetic Testing Error 404: Gene Not Found’ and ‘Examining Why Less Than Half of All Who Have Charcot-Marie-Tooth Disease Are Not Able to Obtain Genetic Confirmation of Their Disease.


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